Objective: To determine the effects of exercise in anatomic abnormalities of the pelvic floor (SP) and the quality of life (QOL) of women with stress urinary incontinence (SUI). Method: An experimental study with 50 women with SUI, distributed randomly into two groups, experimental (GE, 49.24±7.37 years) and control group (CG; 45.25±5.60 years). The groups performed ultrasound evaluation of the SP, evidence of pelvic floor muscle strength by palpation bidigital, surface EMG motor activity and replied to the CV before and after treatment. The GE had 16 sessions of pelvic floor exercises twice a week for 30min. Results: Comparison between the GE and GC revealed significant differences in favor of GE, namely: mobility of the bladder neck (r=-0.79mm, p=0.00), thickness of pelvic floor muscle (r=-0.04mm, p=0.00), EMG (r=0.05μV, p=0.00), muscle strength by the AFA (r=0.05 level, p=0.00), DOMI1 (r%=5.67%, p=0.00), DOMI2 (r%=18.00%, p=0.00), DOMI3 (r%=18.22%, p=0.00), DOMI4 (r%=4.45%, p=0.00), DOMI5 (r%=0.22%, p=0.00), DOMI6 (r%=2.00%, p=0.00), DOMI7 (r%=3.78%, p=0, 00), DOMI8 (r%=6.33%, p=0.00), DOMI9 (r%=4.03%, p=0.00). Conclusion: It was modified and improved anatomic features of the pelvic floor of women from GE through perineal exercises, which will positively influence the CV of these women.

Objetivo: Verificar el efecto de los ejercicios en las alteraciones anatomofuncionales del suelo pélvico (SP) y en la calidad de vida (CV) de mujeres con incontinencia urinaria de esfuerzo (IUE). Método: Estudio experimental realizado con 50 mujeres con IUE, distribuidas de forma aleatoria en: grupo experimental (GE; 49,24±7,37 años) y grupo control (GC; 45,25±5,60 años). Los grupos realizaron evaluación ecográfica del SP, prueba de fuerza muscular del suelo pélvico por medio de la palpación bidigital, actividad motora electromiográfica de superficie y contestaron al cuestionario CV antes y después del tratamiento. El GE hizo 16 sesiones de ejercicios para el suelo pélvico, dos veces a la semana, durante 30min. Resultados: La comparación entre el GE y el GC reveló diferencias significativas a favor del GE, a saber: movilidad del cuello vesical (r=-0,79mm, p=0,00), espesor de los músculos del suelo pélvico (r=-0,04mm, p=0,00), EMG (r=0,05μV, p=0,00), fuerza muscular por el AFA (r=0,05 grado, p=0,00), DOMI1 (r%=5,67%, p=0,00), DOMI2 (r%=18,00%, p=0,00), DOMI3 (r%=18,22%, p=0,00), DOMI4 (r%=4,45%, p=0,00), DOMI5 (r%=0,22%, p=0,00), DOMI6 (r%=2,00%, p=0,00), DOMI7 (r%=3,78%, p=0,00), DOMI8 (r%=6,33%, p=0,00), DOMI9 (r%=4,03%, p=0,00). Conclusión: Se modificaron y se mejoraron las características anatomofuncionales del suelo pélvico de las mujeres del GE a través de ejercicios perineales, lo que influyó de forma positiva en la CV de esas mujeres.

Several natural compounds have been identified for the treatment of leishmaniasis. Among them are some alkaloids, chalcones, lactones, tetralones, and saponins. The new compound reported here, 7-geranyloxycoumarin, called aurapten, belongs to the chemical class of the coumarins and has a molecular weight of 298.37. The compund was extracted from the Rutaceae species Esenbeckia febrifuga and was purified from a hexane extract starting from 407.7 g of dried leaves and followed by four silica gel chromatographic fractionation steps using different solvents as the mobile phase. The resulting compound (47 mg) of shows significant growth inhibition with an LD50 of 30 µM against the tropical parasite Leishmania major, which causes severe clinical manifestations in humans and is endemic in the tropical and subtropical regions. In the present study, we investigated the atomic structure of aurapten in order to determine the existence of common structural motifs that might be related to other coumarins and potentially to other identified inhibitors of Leishmania growth and viability. This compound has a comparable inhibitory activity of other isolated molecules. The aurapten is a planar molecule constituted of an aromatic system with electron delocalization. A hydrophobic side chain consisting of ten carbon atoms with two double bonds and negative density has been identified and may be relevant for further compound synthesis.